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Development of Wearable Semi-invasive Blood Sampling Devices for Continuous Glucose Monitoring: A Survey  [PDF]
Gang Wang, Martin P. Mintchev
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.55B009
Abstract: Semi-invasive blood sampling devices mimic the way female mosquitoes extract blood from a host. They generally consist of a microneedle, a microactuator for needle insertion, a blood extraction mechanism and a blood glucose sensor. These devices have great potential to overcome the major disadvantages of several current blood glucose monitoring methods. Over last two decades, extensive research has been made in all of these related fields. More recently, several wearable devices for semi-invasive blood sampling have been developed. This review aims at summarizing the current state-of-the-art development and utilization of such wearable devices for continuous monitoring of blood glucose levels, with a special attention on design considerations, fabrication technologies and testing methods.
A faithful tensor space representation for the blob algebra
P P Martin
Mathematics , 2003,
Abstract: We show that a certain tensor space representation of the blob algebra (an affine Hecke algebra quotient) is faithful.
Pascal's triangle and word bases for blob algebra ideals
P P Martin
Mathematics , 2007,
Abstract: We give an elementary proof of isomorphism of the blob (diagram) algebra and the corresponding extended Temperley-Lieb algebra (defined by presentation).
Polymer Supported Lipid Bilayers  [PDF]
Ian P. McCabe, Martin B. Forstner
Open Journal of Biophysics (OJBIPHY) , 2013, DOI: 10.4236/ojbiphy.2013.31A008
Abstract:

Lipid bilayers are some of the most fascinating self-assembled structure in living nature. Not only do they serve as the protective boundary of cells and their internal organelles, they also organize and host major parts of the biochemical machinery for cellular communication and transmembrane transport. To study aspects of cellular membranes in a controlled manner, solid supported planar bilayers have served as reliable tools for many decades. They have been used in a large variety of studies ranging from fundamental investigations of membranes and their constituents to the dissection of cellular signaling mechanisms. However, there are limitations to these systems and recently a class of new systems in which the lipid bilayer is supported on a soft, polymer cushion has emerged. Here, we review the different polymer cushioned bilayer systems and discuss their manufacture and advantages.

Pseudobezoars: Technology Progress and New Prospects as a Medical Platform  [PDF]
Orly Yadid-Pecht, Martin P. Mintchev
Engineering (ENG) , 2013, DOI: 10.4236/eng.2013.55B003
Abstract: In recent years, pseudobezoars have been a subject of research, mainly serving as a basis for a new non-invasive alternative to obesity treatment. A pill incorporating the technology has been proven to be successful as a weight loss therapy. It enables patients to sustain a diet longer, due to an increase in the level of satiety, resulting in a smaller amount of food intake. Utilization of the technology has recently found new prospects in another organ of the GI tract, the colon. Pseudobezoar technology can be utilized as an enhanced method for colon cancer screening and also as an alternative carrier for bacterial therapy.
Numerical Investigation of Effective Heat Conductivity of Fluid in Charging Process of Thermal Storage Tank  [PDF]
Hadi Taheri, Ferdinand P. Schmidt, Martin Gabi
Open Journal of Fluid Dynamics (OJFD) , 2015, DOI: 10.4236/ojfd.2015.51006
Abstract: This paper presents a numerical case study of heat transfer mechanisms during the charging process of a stratified thermal storage tank applied in a specific adsorption heat pump cycle. The effective thermal conductivity of the heat transfer fluid during the charging process is analyzed through CFD simulations using Unsteady Reynolds-averaged Navier-Stokes equations (URANS). The aim of the study is to provide an equivalent thermal conductivity for a one-dimensional storage tank model to be used in a system simulation of the complete adsorption heat pump cycle. The influence of the turbulent mixing and also the advection effect due to fluid bulk motion are investigated. The results show that in the case considered here, the turbulence effect on the effective thermal conductivity is more considerable than the advection effect.
An Evaluation Methodology Development and Application Process for Severe Accident Safety Issue Resolution
Robert P. Martin
Science and Technology of Nuclear Installations , 2012, DOI: 10.1155/2012/735719
Abstract: A general evaluation methodology development and application process (EMDAP) paradigm is described for the resolution of severe accident safety issues. For the broader objective of complete and comprehensive design validation, severe accident safety issues are resolved by demonstrating comprehensive severe-accident-related engineering through applicable testing programs, process studies demonstrating certain deterministic elements, probabilistic risk assessment, and severe accident management guidelines. The basic framework described in this paper extends the top-down, bottom-up strategy described in the U.S Nuclear Regulatory Commission Regulatory Guide 1.203 to severe accident evaluations addressing U.S. NRC expectation for plant design certification applications. 1. Introduction Associated with rare, hazardous events, such as nuclear power plant (NPP) severe accidents, is a degree of uncertainty that provides a significant challenge to the evaluation and resolution of related design and analysis methods issues. For events occurring at some sufficiently observable frequency, design improvements can evolve through the understanding gained from such events and applicable test programs, leading to long-term acceptance. The broad uncertainties associated with severe accident initiators and event progression impose inherent limits on the benefits of this approach for severe accident design. As such, there is greater reliance on analysis and emphasis on the better understood severe accident phenomena. The engineering design process for an NPP’s severe accident response strategy has evolved to a process that relies on the(i)establishment of safety goals,(ii)identification of processes and phenomena,(iii)iterative design processes focused on risk reduction,(iv)test programs,(v)expert elicitation on important severe accident safety issues,(vi)analysis methods development,(vii)process studies. Consistent with current US regulatory requirements and guidance, final acceptance and resolution of relevant beyond-design-basis events is demonstrated through detailed deterministic studies and probabilistic risk assessment (PRA). The unique characteristic of this process for severe accidents is the consideration of risk in the resolution of severe accident safety issues. Generation III and IV advanced reactors designs incorporate features that significantly reduced risk relative to current-generation light water reactors (LWRs). Practical consideration of this reduced risk requires that this information be incorporated into measures not only of acceptable performance,
Hesiod and The Didactic Double
Martin,Richard P.;
Synthesis (La Plata) , 2004,
Abstract: an unusual feature of hesiod's didactic strategy in the works and days is the inclusion of his brother, perses, as addressee. whether or not there is an historical basis for the financial dispute between the brothers as represented in the poem is of less interest than the stance that such a (possibly fictional) situation entails. for the advisor-figure, hesiod, naturally maintains a different attitude toward a brother than he would if his advisee were a son, a future king, or a student---all of which roles are more typical in the didactic traditions attested in world literature. this paper goes on to explore the tensions, mythic resonances, and ambiguities inherent in the choice of the brother-figure as recipient of advice, and concludes that this particular didactic configuration provides a more open-ended and acceptable entry through which any audience can interact with the wisdom traditions enshrined in hesiodic verse.
The top squark-mediated annihilation scenario and direct detection of dark matter in compressed supersymmetry
Martin, Stephen P.
High Energy Physics - Phenomenology , 2007, DOI: 10.1103/PhysRevD.76.095005
Abstract: Top squark-mediated annihilation of bino-like neutralinos to top-antitop pairs can play the dominant role in obtaining a thermal relic dark matter abundance in agreement with observations. In a previous paper, it was argued that this can occur naturally in models of compressed supersymmetry, which feature a running gluino mass parameter that is substantially smaller than the wino mass parameter at the scale of apparent gauge coupling unification. Here I study in some more detail the parameter space in which this is viable, and compare to other scenarios for obtaining the observed dark matter density. I then study the possibility of detecting the dark matter directly in future experiments. The prospects are consistently very promising for a wide variety of model parameters within this scenario.
Exploring compressed supersymmetry with same-sign top quarks at the Large Hadron Collider
Martin, Stephen P.
High Energy Physics - Phenomenology , 2008, DOI: 10.1103/PhysRevD.78.055019
Abstract: In compressed supersymmetry, a light top squark naturally mediates efficient neutralino pair annihilation to govern the thermal relic abundance of dark matter. I study the LHC signal of same-sign leptonic top-quark decays from gluino and squark production, which follows from gluino decays to top plus stop followed by the stop decaying to a charm quark and the LSP in these models. Measurements of the numbers of jets with heavy-flavor tags in the same-sign lepton events can be used to confirm the origin of the signal. Summed transverse momentum observables provide an estimate of an effective superpartner mass, which is correlated with the gluino mass. Measurements of invariant mass endpoints from the visible products of gluino decays do not allow direct determination of superpartner masses, but can place constraints on them, including lower bounds on the gluino mass as a function of the top-squark mass.
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